Bryan McEntire, Ph.D.
Chief Scientific Officer, SINTX Technologies, Inc.
BIOGRAPHYBryan J. McEntire, Ph.D., is currently Chief Scientific Officer for SINTX Technologies Inc., a position which he has held since 2012. He previously served as Vice President of Manufacturing from 2004 and Vice President of Research from 2006. He received BS (cum laude) and MBA degrees in Materials Science and Engineering and Operations Management from the University of Utah in 1978 and 1982, respectively, and his Ph.D. from the Kyoto Institute of Technology in 2015. Dr. McEntire has more than 40 years of industrial experience in research, development, and production of advanced ceramics, including prominent management positions at Ceramatec (Salt Lake City, UT, USA), Saint-Gobain Industrial Ceramics Corporation (Northboro, MA, and E. Granby, CT, USA), Applied Materials Corporation (Santa Clara, CA, USA), and now at SINTX Technologies (Salt Lake City, UT, USA). Dr. McEntire is author or co-author of over 130 peer reviewed publications and holds eight patents. He was an invited short-course lecturer to the National Institute of Ceramic Engineers of the American Ceramic Society on the forming of ceramics for a 10-year period from 1986 to 1995. He was nominated and elevated to Fellow of the American Ceramic Society in 2012. His current research interests are in silicon nitride for biomedical applications.
10:15 am - 11:15 am
A Novel Antipathogenic Agent for Nonwoven Fabric
One strategy to prevent the spread of airborne pathogens is the use of medical-grade face masks or N95 respirators. Unlike commercial cloth masks, these devices assure a higher level of protection by incorporating multiple layers of hydrophobic nonwoven fabric. While they may trap respiratory droplets and aerosols, these devices generally cannot inactivate or lyse pathogens. To address this limitation, antimicrobial agents such as silver, copper, zinc, iodine, organic acids, chitosan, peptides, quaternary ammonium salts, and nanoparticles have been embedded in the nonwoven scrim. The effectiveness of most of these compounds has yet to be clinically demonstrated, and their value remains debatable because they can also be toxins, allergens, or irritants. In addition, they may be limited in their bacterial or viricidal efficacy. Recently, a novel antipathogenic material has been developed that may be the ideal antimicrobial agent. Silicon nitride (Si3N4) is a bioceramic that is FDA cleared for spinal fusion surgery. The material is highly effective in inactivating a variety of bacteria, fungi, and viruses, including SARS-CoV-2. Several independent studies have shown that Si3N4 powder annihilates pathogens essentially on contact while remaining remarkably friendly to mammalian tissue. This novel antipathogenic technology is now being incorporated into scrim for use in facial masks, purifiers, and similar air-filtering applications. Its combination with the nonwoven fabric provides an effective “catch-and-kill” platform to trap microbes and inactivate them. This presentation will review the science and technology supporting the development of Si3N4 as an antipathogenic agent for nonwoven fabric.